The report "Protein A Resin Market by Product (Agarose-based, Glass/Silica-based, Organic polymer-based), Type (Recombinant Protein A, Natural Protein A), Application (Antibody Purification, Immunoprecipitation), End User & Region - Global Forecasts to 2028", is projected to reach USD 2.1 billion by 2028 from USD 1.2 billion in 2022, growing at a CAGR of 9.8% during the forecast period. Factors such as increasing research activities, expanding therapeutic applications of monoclonal antibodies, private along with public fundings, spending on pharmaceutical R&D, growing food safety concerns, and stringent regulatory control in healthcare are expected to propel the growth of this market. However, the high cost of the resin is expected to restrain the market growth.
The global protein A resin market is being driven by the increasing demand for biopharmaceuticals, such as monoclonal antibodies, and the growing demand for therapeutic proteins. The growth of the biopharmaceutical industry is also driving the demand for protein A resin, as it is used in the production of biologics, such as monoclonal antibodies and recombinant proteins. Moreover, the increasing demand for high purity and high quality proteins is driving the growth of the protein A resin market.
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The increasing demand for biopharmaceuticals is driving the growth of the protein A resin market. Protein A is a bacterial protein used in affinity chromatography for the purification of antibodies, such as IgG and IgM. It has a high affinity for the Fc (fragment crystallizable) region of antibodies, which allows it to be used for the selective purification of antibodies from complex solutions.
Protein A resin is a powerful tool used in bioprocessing, helping to purify and separate proteins from biological solutions. It is an affinity resin, meaning it selectively binds proteins by recognizing specific proteins in a solution. This makes it ideal for the purification of antibodies, which are proteins that are used to detect and bind to other proteins or molecules.
In bioprocessing, protein A resin is used to separate proteins from biological solutions. It works by binding to the Fc region of antibodies, which is a region of the antibody that is recognized by Protein A. This binding helps to separate the antibodies from the solution, allowing researchers to easily purify and isolate the desired protein.
The process of using Protein A resin is relatively simple. First, the sample is passed through a column containing the resin. The Protein A then binds to the Fc region of the antibodies, forming a complex. The complex is then washed to remove any unbound proteins or molecules. Finally, the bound proteins are eluted from the column, allowing them to be collected.
Protein A resin is an invaluable tool for bioprocessing and protein purification, as it helps to quickly and easily separate proteins from a biological solution. It is a reliable, cost-effective method that is used in a variety of research and medical applications.
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Protein A Resin Market Dynamics
Drivers: Increasing demand for therapeutic antibodies
Chromatography is an essential step in the purification of monoclonal antibodies (mAbs). Over the past decade, there has been a tremendous increase in the demand for monoclonal antibodies in oncology and several other therapeutic areas, including neurological, autoimmune, and inflammatory disorders. As a result, almost all major pharmaceutical companies are focusing on the R&D of therapeutic antibodies.
Restrains: High cost of resins
Protein A resins cost around 5-10 times more than other types of resins. Though there are no alternative techniques that can achieve purification levels as high as protein A resins, their high cost makes end users look for alternatives. Some of the techniques that provide acceptable levels of purification include both chromatography and non-chromatography methods. mAb crystallization and precipitation by polyethylene glycol (PEG) precipitation are being explored as alternatives for protein A chromatography.
Opportunities: Increasing number of CMOs and CROs
An increasing number of CMOs and CROs are offering their services to pharmaceutical companies across the globe. This is expected to offer potential growth opportunities to protein A resin manufacturers during the forecast period. Pharmaceutical companies are increasingly relying on contract manufacturers in various areas of research to fulfill a number of basic needs, such as specialized competencies and cost reduction. The pharmaceutical contract manufacturing industry has experienced robust growth in recent years, and this trend is expected to continue in the coming years.
Kay Market Players
The prominent players in the global protein A resin market include GE Healthcare (US), Merck Millipore (Germany), Repligen Corporation (US), Thermo Fisher Scientific (US), Tosoh Bioscience (Japan), Purolite Corporation (US), Novasep Holding SAS (France), Agilent Technologies (US), GenScript Biotech Corporation (China), PerkinElmer (US), Bio-Rad Laboratories (US), Orochem (US), Kaneka Corporation (Japan), Abcam (UK), Agarose Bead Technologies (US), Avantor (US), JSR Life Sciences (US), Bio-Works Technologies (Sweden), Amikozen Co. Ltd. (US), and Takara Bio Inc. (Japan).
Key Topics Covered in Protein A Resin Market:
Chapter 1. Market Synopsis
Chapter 2. Executive Summary
Chapter 3. Indicative Metrics
Chapter 4. Protein A Resin Market Segmentation & Impact Analysis
Chapter 5. Protein A Resin Market By Product Insights & Trends
Chapter 6. Protein A Resin Market By Application Insights & Trends
Chapter 7. Protein A Resin Market By End-use Insights & Trends
Chapter 8. Protein A Resin Market Regional Outlook
Chapter 9. Competitive Landscape
Chapter 10. Company Profiles
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